While you are taking SUTENT^®, you may have questions or concerns about your treatment. Listed here are a few common questions about SUTENT and answers you may find useful.

Remember: Your doctor or nurse can talk with you about any questions or concerns you have.

Q: What is SUTENT?
A: SUTENT is an anticancer drug that you take by mouth. SUTENT is used when the medicine Gleevec^® does not stop the cancer from growing or when you cannot take Gleevec.

Q: What are the benefits of taking SUTENT?
A: SUTENT may slow or stop the growth of your cancer. It may also help shrink your tumors. SUTENT may not work the same for every person.

Q: How do I know if SUTENT is working?
A: When you visit your doctor, you will have special scans or tests to check the size of your tumors. Your doctor or nurse will discuss these tests with you. The scans and tests may show if the tumors are growing, staying the same size, or shrinking.

Q: What serious side effects might I have while taking SUTENT?
A: SUTENT can cause serious liver problems, including death. Tell your doctor right away if you develop any of the following signs and symptoms of liver problems during treatment with SUTENT:

• Itching
• Yellow eyes or skin
• Dark urine
• Pain or discomfort in the right upper stomach area

Your doctor should do blood tests to check your liver function before you start taking SUTENT and during treatment.

SUTENT may cause heart problems, including:

• Heart failure
• Heart muscle problems (cardiomyopathy)
• Tell your doctor if you feel dizzy, faint, very tired, have abnormal heartbeats, are short of breath, or have swollen feet and ankles
• Abnormal heart rhythm changes
• Your doctor may do electrocardiograms and blood tests to watch for these problems during your treatment with SUTENT. Tell your doctor if you feel dizzy, faint, or have abnormal heartbeats while taking SUTENT

SUTENT may cause high blood pressure. Your doctor may check your blood pressure during treatment with SUTENT. He or she may prescribe medicine for you to treat high blood pressure, if needed.

SUTENT may cause bleeding sometimes leading to death. Tell your doctor right away if you have any of following symptoms during treatment with SUTENT:

• Serious bleeding problem
• Painful swollen stomach (abdomen)
• Vomiting blood
• Black sticky stools
• Bloody urine
• Headache or change in your mental status

Your doctor can tell you other symptoms to watch for.

SUTENT may cause hormone problems, including thyroid and adrenal gland problems. Your doctor may do tests to check your thyroid and adrenal gland function during SUTENT treatment. Tell your doctor if you have any of the following signs and symptoms during treatment with SUTENT:

• Tiredness that worsens and does not go away
• Loss of appetite
• Heat intolerance
• Feeling nervous or agitated, tremors
• Sweating
• Nausea or vomiting
• Diarrhea
• Fast heart rate
• Weight gain or weight loss
• Feeling depressed
• Irregular menstrual periods or no menstrual periods
• Headache
• Hair loss

Q: What other side effects might I have while taking SUTENT?
A: Patients who take SUTENT have these side effects more often than other side effects:

• The medicine in SUTENT is yellow, and it may make your skin look yellow. Your skin and hair may get lighter in color
• Tiredness
• Weakness
• Fever
• Gastrointestinal symptoms, including diarrhea, nausea, vomiting, mouth sores, upset stomach, abdominal pain, and constipation. Talk with your healthcare provider about ways to handle these problems
• Rash or other skin changes, including drier, thicker, or cracking skin
• Blisters or a rash on the palms of your hands and soles of your feet
• Taste changes
• Loss of appetite
• Pain or swelling in your arms or legs
• Cough
• Shortness of breath
• Bleeding, such as nosebleeds or bleeding from cuts

Call your healthcare provider if you have any swelling or bleeding during treatment with SUTENT.

These are not all possible side effects of SUTENT. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

You may have had some of the side effects listed above before starting treatment with SUTENT. Be sure to tell your healthcare provider if there is any change or increase in your side effects.

Q: Will my skin and/or hair change color?
A: Color change is not harmful or painful. If you have light or fair skin, you may see a yellow tint in your skin. If your skin is darker, it may lighten all over or in patches. Your hair may lighten in patches. Yellow eyes or skin may also be a sign of serious liver problems. Tell your healthcare provider right away if you develop yellow eyes or skin.

Q: Will my natural skin and hair color come back?
A: Your natural skin or hair color will usually return after stopping treatment with SUTENT.

Q: What signs or symptoms should I watch for?
A: You should tell your doctor or nurse right away if you have any of these:

Itching Yellow eyes or skin Dark urine Pain or discomfort in the right upper stomach area A serious bleeding problem Painful swollen stomach (abdomen) Vomiting blood Black sticky stools Bloody urine Headache or change in your mental status Loss of appetite Headache

Heat intolerance Feeling nervous or agitated, tremors Sweating Nausea or vomiting Diarrhea Fast heart rate Weight gain or weight loss Feeling depressed Irregular menstrual periods or no menstrual periods Tiredness that worsens and does not go away Hair loss

Q: Will SUTENT react with any other drugs I’m taking or products I’m using?
A: Using SUTENT with other medicines can cause serious side effects. Tell your doctor about all the medicines, vitamins, or herbal products you use.

Do not drink grapefruit juice or eat grapefruit during your treatment with SUTENT. This may cause you to have too much SUTENT in your body.

Q: Where can I find information about insurance coverage for SUTENT?
A: First Resource^® offers many services to help you access Pfizer medicines. A simple phone call can start the process. You can call First Resource at (877) 744-5675.